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KMID : 0358420110540090508
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Korean Journal of Obstetrics and Gynecology
2011 Volume.54 No. 9 p.508 ~ p.516
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The effect of udenafil (zydena) on the fertilization and early embryo development in mice
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Chun Geun-Soo
Sim Jae-Chul
Yang Hoe-Saeng
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Abstract
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Objective :To determine the effect of udenafil, a cyclic monophosphate-specific type 5 phosphodiesterase inhibitor, on fertilization and early embryo cleavage of mice.
Methods:This mammal study included randomly assigned male and female mice. The females were sacrificed after mating to evaluate their oocytes and embryos in four different time intervals following the treatment. Female mice were injected intraperitoneally with 5 IU of gonadotropin and human chorionic gonadotropin to stimulate follicular growth and induce ovulation. They were separately caged with males that had been gavaged with udenafil (0.06 mg/0.05 mL) and allowed to mate. After 24, 48, 72, and 96 hours of time intervals, females were killed, their oviducts were dissected out, and retrieved embryos were assessed for blastomere number and quality. Fertilization rates and numbers of embryos were evaluated after treatment.
Results:Fertilization rates were reduced in females that were mated with udenafil gavaged males. Over days 2-4, the numbers of embryo that of the treated group were significantly fewer than in the control group. There was also a tendency of impaired cleavage rates with those embryos.
Conclusion:The impairments of fertility caused by udenafil have important implications for infertility centers and couples who are using this drug precoitally while attempting to conceive.
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KEYWORD
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Udenafil, Fertilization, Embryo cleavage
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